검색어 : 통합검색[Symons Julian]
총 113건 중 113건 출력
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91
- TOP-357 Second generation HBV siRNAs with novel chemistries demonstrate improved profiles compared with ALG-125755 and other clinical stage siRNAs
- Hong, Jin; Rajwanshi, Vivek; Montero, Saul; Luo, Min; Passow, Kellan; Liu, Cheng; Kang, Hyunsoon; Sousa, Jacquelyn; Cho, Dana; Cortez, John; Daguison, Shane; Gupta, Kusum; Tan, Hua; Huang, Vera; Cai, Dawei; Ahmed-Belkacem, Rostom; Blatt, Lawrence; Smith, David; Beigelman, Leonid; Symons, Julian; ; (Journal of hepatology : the journal of the European Association for the Study of the Liver, v.80, 2024, pp.S727-S728)
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92
- Discovery of 4′-Chloromethyl-2′-deoxy-3′,5′-di-<i>O</i>-isobutyryl-2′-fluorocytidine (ALS-8176), A First-in-Class RSV Polymerase Inhibitor for Treatment of Human Respiratory Syncytial Virus Infection
- Wang, Guangyi; Deval, Jerome; Hong, Jin; Dyatkina, Natalia; Prhavc, Marija; Taylor, Joshua; Fung, Amy; Jin, Zhinan; Stevens, Sarah K.; Serebryany, Vladimir; Liu, Jyanwei; Zhang, Qingling; Tam, Yuen; Chanda, Sushmita M.; Smith, David B.; Symons, Julian A.; Blatt, Lawrence M.; Beigelman, Leo; ; (Journal of medicinal chemistry, v.58, 2015, pp.1862-1878)
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93
- ALG-000184, a prodrug of capsid assembly modulator ALG-001075, demonstrates best-in-class preclinical characteristics for the treatment of chronic hepatitis B
- Zhang, Qingling; Vendeville, Sandrine; Serebryany, Vladimir; Welch, Michael; Liu, Jyanwei; Williams, Caroline; Debing, Yannick; Jekle, Andreas; Stevens, Sarah; Deval, Jerome; Lin, Tse-I; Misner, Dinah; Chanda, Sushmita; Schinazi, Raymond F; Raboisson, Pierre; Symons, Julian; Blatt, Lawrence; Beigelman, Leonid; Smith, David; ; (Journal of hepatology : the journal of the European Association for the Study of the Liver, v.73, 2020, pp.S880-S881)
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94
- Selection and Characterization of Replicon Variants Dually Resistant to Thumb- and Palm-Binding Nonnucleoside Polymerase Inhibitors of the Hepatitis C Virus
- Le Pogam, Sophie; Kang, Hyunsoon; Harris, Seth F.; Leveque, Vincent; Giannetti, Anthony M.; Ali, Samir; Jiang, Wen-Rong; Rajyaguru, Sonal; Tavares, Gisele; Oshiro, Connie; Hendricks, Than; Klumpp, Klaus; Symons, Julian; Browner, Michelle F.; Cammack, Nick; Ná jera, Isabel; Roche Palo Alto LLC, 3431 Hillview Avenue, Palo Alto, California 94304; Roche Palo Alto LLC, 3431 Hillview Avenue, Palo Alto, California 94304; Roche Palo Alto LLC, 3431 Hillview Avenue, Palo Alto, California 94304; Roche Palo Alto LLC, 3431 Hillview Avenue, Palo Alto, California 94304; Roche Palo Alto LLC, 3431 Hillview Avenue, Palo Alto, California 94304; Roche Palo Alto LLC, 3431 Hillview Avenue, Palo Alto, California 94304; Roche Palo Alto LLC, 3431 Hillview Avenue, Palo Alto, California 94304; Roche Palo Alto LLC, 3431 Hillview Avenue, Palo Alto, California 94304; Roche Palo Alto LLC, 3431 Hillview Avenue, Palo Alto, California 94304; Roche Palo Alto LLC, 3431 Hillview Avenue, Palo Alto, California 94304; Roche Palo Alto LLC, 3431 Hillview Avenue, Palo Alto, California 94304; Roche Palo Alto LLC, 3431 Hillview Avenue, Palo Alto, California 94304; Roche Palo Alto LLC, 3431 Hillview Avenue, Palo Alto, California 94304; Roche Palo Alto LLC, 3431 Hillview Avenue, Palo Alt; (Journal of virology, v.80, 2006, pp.6146-6154)
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95
- Synthesis and Anti-Influenza Activity of Pyridine, Pyridazine, and Pyrimidine <i>C</i>-Nucleosides as Favipiravir (T-705) Analogues
- Wang, Guangyi; Wan, Jinqiao; Hu, Yujian; Wu, Xiangyang; Prhavc, Marija; Dyatkina, Natalia; Rajwanshi, Vivek K.; Smith, David B.; Jekle, Andreas; Kinkade, April; Symons, Julian A.; Jin, Zhinan; Deval, Jerome; Zhang, Qingling; Tam, Yuen; Chanda, Sushmita; Blatt, Lawrence; Beigelman, Leonid; Alios BioPharma, Inc., part of the Janssen Pharmaceutical Companies, South San Francisco, California 94080,; Department of Medicinal Chemistry, WuXi AppTec, Shanghai 200131,; Department of Medicinal Chemistry, WuXi AppTec, Shanghai 200131,; Department of Medicinal Chemistry, WuXi AppTec, Shanghai 200131,; Alios BioPharma, Inc., part of the Janssen Pharmaceutical Companies, South San Francisco, California 94080,; Alios BioPharma, Inc., part of the Janssen Pharmaceutical Companies, South San Francisco, California 94080,; Alios BioPharma, Inc., part of the Janssen Pharmaceutical Companies, South San Francisco, California 94080,; Alios BioPharma, Inc., part of the Janssen Pharmaceutical Companies, South San Francisco, California 94080,; Alios BioPharma, Inc., part of the Janssen Pharmaceutical Companies, South San Francisco, California 94080,; Alios BioPharma, Inc., part of the Janssen Pharmaceutical Companies, South San Francisco, California 94080,; Alios BioPharma, Inc., part o; (Journal of medicinal chemistry, v.59, 2016, pp.4611-4624)
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96
- Class A capsid assembly modulator RG7907 clears HBV-infected hepatocytes through core-dependent hepatocyte death and proliferation
- Kum, Dieudonné Buh; Vanrusselt, Hannah; Acosta Sanchez, Abel; Taverniti, Valerio; Verrier, Eloi R.; Baumert, Thomas F.; Liu, Cheng; Deval, Jerome; Corthout, Nikky; Munck, Sebastian; Beigelman, Leonid; Blatt, Lawrence M.; Symons, Julian A.; Raboisson, Pierre; Jekle, Andreas; Vendeville, Sandrine; Debing, Yannick; Aligos Belgium BV, Leuven, Belgium; Aligos Belgium BV, Leuven, Belgium; Novalix, Leuven, Belgium; Strasbourg University, Inserm, Institute for Research on Viral and Hepatic Diseases, UMR S1110, Strasbourg, France; Strasbourg University, Inserm, Institute for Research on Viral and Hepatic Diseases, UMR S1110, Strasbourg, France; Strasbourg University, Inserm, Institute for Research on Viral and Hepatic Diseases, UMR S1110, Strasbourg, France; Aligos Therapeutics Inc., South San Francisco, California, USA; Aligos Therapeutics Inc., South San Francisco, California, USA; VIB Bio-imaging Core, Leuven, Belgium; VIB Bio-imaging Core, Leuven, Belgium; Aligos Therapeutics Inc., South San Francisco, California, USA; Aligos Therapeutics Inc., South San Francisco, California, USA; Aligos Therapeutics Inc., South San Francisco, California, USA; Aligos Belgium BV, Leuven, Belgium; Aligos Therapeutics Inc., South San Francisco, California, USA; Aligos Belgium BV, Leuven, Belgium; Alig; (Hepatology : official journal of the American Association for the Study of Liver Diseases, v.78, 2023, pp.1252-1265)
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97
- Novel non-HAP class A HBV capsid assembly modulators have distinct <i>in vitro</i> and <i>in vivo</i> profiles
- Vanrusselt, Hannah; Kum, Dieudonné Buh; Taverniti, Valerio; Liu, Cheng; Acosta Sanchez, Abel; Corthout, Nikky; Munck, Sebastian; Baumert, Thomas F.; Beigelman, Leonid; Blatt, Lawrence M.; Symons, Julian A.; Deval, Jerome; Raboisson, Pierre; Verrier, Eloi R.; Jekle, Andreas; Vendeville, Sandrine; Debing, Yannick; Aligos Belgium BV , Leuven, Belgium; Aligos Belgium BV , Leuven, Belgium; Inserm, Institut de Recherche sur les Maladies Virales et Hé patiques UMR S1110, Université de Strasbourg , Strasbourg, France; Aligos Therapeutics, Inc. , South San Francisco, California, USA; Novalix , Leuven, Belgium; VIB Bio-imaging Core , Leuven, Belgium; VIB Bio-imaging Core , Leuven, Belgium; Inserm, Institut de Recherche sur les Maladies Virales et Hé patiques UMR S1110, Université de Strasbourg , Strasbourg, France; Aligos Therapeutics, Inc. , South San Francisco, California, USA; Aligos Therapeutics, Inc. , South San Francisco, California, USA; Aligos Therapeutics, Inc. , South San Francisco, California, USA; Aligos Therapeutics, Inc. , South San Francisco, California, USA; Aligos Belgium BV , Leuven, Belgium; Inserm, Institut de Recherche sur les Maladies Virales et Hé patiques UMR S1110, Université de Strasbourg , Strasbourg, France; Aligos Therapeu; (Journal of virology : JVI, v.97, 2023, pp.e00722-23)
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98
- Regulation of gene transcription by thyroid hormone receptor β agonists in clinical development for the treatment of non-alcoholic steatohepatitis (NASH)
- Luong, Xuan G.; Stevens, Sarah K.; Jekle, Andreas; Lin, Tse-I; Gupta, Kusum; Misner, Dinah; Chanda, Sushmita; Mukherjee, Sucheta; Williams, Caroline; Stoycheva, Antitsa; Blatt, Lawrence M.; Beigelman, Leonid N.; Symons, Julian A.; Raboisson, Pierre; McGowan, David; Vandyck, Koen; Deval, Jerome; Aligos Therapeutics, Inc., South San Francisco, California, United States of America; Aligos Therapeutics, Inc., South San Francisco, California, United States of America; Aligos Therapeutics, Inc., South San Francisco, California, United States of America; Aligos Belgium BV, Leuven, Belgium; Aligos Therapeutics, Inc., South San Francisco, California, United States of America; Aligos Therapeutics, Inc., South San Francisco, California, United States of America; Aligos Therapeutics, Inc., South San Francisco, California, United States of America; Aligos Therapeutics, Inc., South San Francisco, California, United States of America; Aligos Therapeutics, Inc., South San Francisco, California, United States of America; Aligos Therapeutics, Inc., South San Francisco, California, United States of America; Aligos Therapeutics, Inc., South San Francisco, California, United States of America; Aligos Therapeutics, Inc., South San Francisco, California, United States of America; Aligos; (PloS one, v.15, 2020, pp.e0240338)
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99
- Proton relative biological effectiveness (RBE) for survival in mice after thoracic irradiation with fractionated doses
- Gueulette, John; Bö hm, Lothar; Slabbert, Jacobus P; De Coster, Blanche M; Rutherfoord, Gerald S; Ruifrok, Arnout; Octave-Prignot, Michelle; Binns, Peter J; Schreuder, A.Nicholaas; Symons, Julian E; Scalliet, Pierre; Jones, Dan T.L; ; (International journal of radiation oncology, biology, physics, v.47, 2000, pp.1051-1058)
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100
- TOP-358-YI Non-HAP CAM-A ALG-006746 and ALG-006780 induce rapid HBsAg reductions in AAV-HBV mice and have favorable pharmacokinetic profiles
- Vanrusselt, Hannah; Verheyen, Jordi; Gupta, Kusum; Degrauwe, Lars; Liu, Cheng; Sanchez, Abel Acosta; Bollier, Mé lanie; Nshimyumuremyi, Jean-Boris; Verburgh, Benjamin; Peter, Clovis; Zhang, Qingling; Blatt, Lawrence; Beigelman, Leonid; Symons, Julian; Chanda, Sushmita; Smith, David; Jekle, Andreas; Vendeville, Sandrine; McGowan, David; Debing, Yannick; ; (Journal of hepatology : the journal of the European Association for the Study of the Liver, v.80, 2024, pp.S728)
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